New and updated Gene editing and gene therapy pages on ContentLora.https://contentlora.com/enhttps://contentlora.com/wiki/base-editing/https://contentlora.com/wiki/base-editing/Base editing rewrites a single DNA letter without cutting both strands. How it works, the first patients treated, and pivotal trials in 2026.Sat, 10 Oct 2026 00:00:00 GMTWikigene-editinglife-scienceshealthhttps://contentlora.com/wiki/casgevy/https://contentlora.com/wiki/casgevy/Casgevy is the first approved CRISPR medicine, an edited stem cell therapy for sickle cell disease and beta-thalassemia. Approvals, data and status.Sat, 10 Oct 2026 00:00:00 GMTWikigene-editinghealthlife-scienceshttps://contentlora.com/wiki/crispr-cas9/https://contentlora.com/wiki/crispr-cas9/CRISPR-Cas9 is the RNA-guided DNA-cutting tool behind modern gene editing and the first approved CRISPR medicine. Origins, uses and limits.Sat, 10 Oct 2026 00:00:00 GMTWikigene-editinglife-scienceshealthhttps://contentlora.com/wiki/crispr-therapeutics/https://contentlora.com/wiki/crispr-therapeutics/CRISPR Therapeutics is the Swiss-based gene-editing company behind Casgevy with Vertex, now running in vivo CRISPR trials in heart and liver disease.Sat, 10 Oct 2026 00:00:00 GMTWikigene-editinghealthlife-scienceshttps://contentlora.com/wiki/intellia-therapeutics/https://contentlora.com/wiki/intellia-therapeutics/Intellia Therapeutics develops in vivo CRISPR therapies. Lonvo-z for hereditary angioedema is under FDA review; nex-z trials resumed after a 2025 hold.Sat, 10 Oct 2026 00:00:00 GMTWikigene-editinghealthlife-scienceshttps://contentlora.com/wiki/lipid-nanoparticle-delivery/https://contentlora.com/wiki/lipid-nanoparticle-delivery/Lipid nanoparticles carry CRISPR and base-editor instructions into the liver. How they work in gene editing, key trials and their limits.Sat, 10 Oct 2026 00:00:00 GMTWikigene-editinglife-scienceshealthhttps://contentlora.com/wiki/personalized-gene-editing/https://contentlora.com/wiki/personalized-gene-editing/Personalized gene editing builds an editor for one patient's mutation. The 2025 CPS1 case, how it was made and how the FDA plans to regulate it.Sat, 10 Oct 2026 00:00:00 GMTWikigene-editinghealthlife-scienceshttps://contentlora.com/wiki/prime-editing/https://contentlora.com/wiki/prime-editing/Prime editing is a "search-and-replace" gene-editing method. How it works, the first human data in 2025, and the road to a first filing.Sat, 10 Oct 2026 00:00:00 GMTWikigene-editinglife-scienceshealthhttps://contentlora.com/events/gene-editing-tracker/https://contentlora.com/events/gene-editing-tracker/A dated, sourced timeline of gene-editing milestones: Casgevy approvals, in vivo CRISPR trials, base and prime editing, FDA actions and safety events.Sat, 10 Oct 2026 00:00:00 GMTDevelopinggene-editinghealthlife-scienceshttps://contentlora.com/analysis/gene-therapy-access-debate/https://contentlora.com/analysis/gene-therapy-access-debate/Gene-editing therapies like Casgevy can cost millions and need specialist centres. The evidence on access, payment models and global reach in 2026.Sat, 10 Oct 2026 00:00:00 GMTAnalysisgene-editinghealthpolicyhttps://contentlora.com/analysis/in-vivo-editing-safety-debate/https://contentlora.com/analysis/in-vivo-editing-safety-debate/In vivo CRISPR therapies are nearing approval, but a 2025 trial death and AAV liver deaths raised safety questions. What the evidence shows.Sat, 10 Oct 2026 00:00:00 GMTAnalysisgene-editinghealthlife-scienceshttps://contentlora.com/explain/gene-editing/https://contentlora.com/explain/gene-editing/A sourced crash course on CRISPR, base and prime editing, delivery, approved therapies like Casgevy and where gene editing stands in October 2026.Sat, 10 Oct 2026 00:00:00 GMTExplainergene-editinglife-scienceshealthhttps://contentlora.com/explain/how-crispr-works/https://contentlora.com/explain/how-crispr-works/How CRISPR-Cas9 finds and cuts DNA, how base and prime editors change DNA without double-strand breaks, and why the difference matters for safety.Sat, 10 Oct 2026 00:00:00 GMTExplainergene-editinglife-scienceshealthhttps://contentlora.com/explain/how-gene-therapy-delivery-works/https://contentlora.com/explain/how-gene-therapy-delivery-works/How gene editors and gene therapies reach cells: editing cells outside the body, viral vectors like AAV and lentivirus, and lipid nanoparticles.Sat, 10 Oct 2026 00:00:00 GMTExplainergene-editinglife-scienceshealth