New and updated Health and medicine pages on ContentLora.https://contentlora.com/enhttps://contentlora.com/wiki/alnylam-pharmaceuticals/https://contentlora.com/wiki/alnylam-pharmaceuticals/Alnylam developed the first approved RNAi drug and is a major siRNA drugmaker. Its medicines, the Amvuttra heart approval and its 2026 pipeline.Sat, 10 Oct 2026 00:00:00 GMTWikivaccines-mrnahealthlife-scienceshttps://contentlora.com/wiki/altos-labs/https://contentlora.com/wiki/altos-labs/Altos Labs is a cell-rejuvenation biotech launched in 2022 with US$3 billion. Its mission, sites, leadership and where it fits in aging research.Sat, 10 Oct 2026 00:00:00 GMTWikilongevitylife-scienceshealthhttps://contentlora.com/wiki/antibody-drug-conjugates/https://contentlora.com/wiki/antibody-drug-conjugates/Antibody-drug conjugates link an antibody to a toxic payload. Not immunotherapy themselves, they are increasingly paired with checkpoint inhibitors.Sat, 10 Oct 2026 00:00:00 GMTWikicancer-immunotherapyhealthlife-scienceshttps://contentlora.com/wiki/base-editing/https://contentlora.com/wiki/base-editing/Base editing rewrites a single DNA letter without cutting both strands. How it works, the first patients treated, and pivotal trials in 2026.Sat, 10 Oct 2026 00:00:00 GMTWikigene-editinglife-scienceshealthhttps://contentlora.com/wiki/biontech/https://contentlora.com/wiki/biontech/BioNTech is the Mainz-based company that co-developed the Pfizer-BioNTech COVID-19 vaccine and is now focused on mRNA cancer immunotherapy.Sat, 10 Oct 2026 00:00:00 GMTWikivaccines-mrnahealthlife-scienceshttps://contentlora.com/wiki/bispecific-t-cell-engagers/https://contentlora.com/wiki/bispecific-t-cell-engagers/Bispecific antibodies bind two targets at once, either linking T cells to tumours or pairing PD-1 with VEGF blockade. Approvals and 2026 trial results.Sat, 10 Oct 2026 00:00:00 GMTWikicancer-immunotherapyhealthlife-scienceshttps://contentlora.com/wiki/brain-initiative/https://contentlora.com/wiki/brain-initiative/The US BRAIN Initiative funds neurotechnology and brain-mapping research. Its 2013 launch, budget swings from $680 million to $320 million, and 2026 rebound.Sat, 10 Oct 2026 00:00:00 GMTWikineurotechlife-scienceshealthhttps://contentlora.com/wiki/cagrisema/https://contentlora.com/wiki/cagrisema/CagriSema combines the amylin analogue cagrilintide with semaglutide. Novo Nordisk's REDEFINE results, the miss against tirzepatide and its FDA review.Sat, 10 Oct 2026 00:00:00 GMTWikimetabolic-medicinehealthlife-scienceshttps://contentlora.com/wiki/calico-life-sciences/https://contentlora.com/wiki/calico-life-sciences/Calico is the aging research company Google announced in 2013. Its mission, AbbVie partnership, pipeline and 2026 milestones.Sat, 10 Oct 2026 00:00:00 GMTWikilongevitylife-scienceshealthhttps://contentlora.com/wiki/car-t-cell-therapy/https://contentlora.com/wiki/car-t-cell-therapy/CAR-T cell therapy: engineered T cells approved for blood cancers since 2017. Approvals, safety rules, the 2026 solid-tumour first and what comes next.Sat, 10 Oct 2026 00:00:00 GMTWikicancer-immunotherapyhealthlife-scienceshttps://contentlora.com/wiki/casgevy/https://contentlora.com/wiki/casgevy/Casgevy is the first approved CRISPR medicine, an edited stem cell therapy for sickle cell disease and beta-thalassemia. Approvals, data and status.Sat, 10 Oct 2026 00:00:00 GMTWikigene-editinghealthlife-scienceshttps://contentlora.com/wiki/cepi/https://contentlora.com/wiki/cepi/CEPI funds vaccines against epidemic threats and leads the 100 Days Mission. Its role in mRNA and pandemic preparedness, and its 2027-2031 plan.Sat, 10 Oct 2026 00:00:00 GMTWikivaccines-mrnahealthlife-scienceshttps://contentlora.com/wiki/crispr-cas9/https://contentlora.com/wiki/crispr-cas9/CRISPR-Cas9 is the RNA-guided DNA-cutting tool behind modern gene editing and the first approved CRISPR medicine. Origins, uses and limits.Sat, 10 Oct 2026 00:00:00 GMTWikigene-editinglife-scienceshealthhttps://contentlora.com/wiki/crispr-therapeutics/https://contentlora.com/wiki/crispr-therapeutics/CRISPR Therapeutics is the Swiss-based gene-editing company behind Casgevy with Vertex, now running in vivo CRISPR trials in heart and liver disease.Sat, 10 Oct 2026 00:00:00 GMTWikigene-editinghealthlife-scienceshttps://contentlora.com/wiki/eli-lilly/https://contentlora.com/wiki/eli-lilly/Eli Lilly makes tirzepatide (Mounjaro, Zepbound) and the GLP-1 pill Foundayo, and is developing retatrutide. Its 2026 results, pipeline and pricing.Sat, 10 Oct 2026 00:00:00 GMTWikimetabolic-medicinehealthlife-scienceshttps://contentlora.com/wiki/er-100/https://contentlora.com/wiki/er-100/ER-100 is the first partial epigenetic reprogramming therapy tested in people, in a Phase 1 trial in glaucoma and NAION. Design, early data and caveats.Sat, 10 Oct 2026 00:00:00 GMTWikilongevitylife-scienceshealthhttps://contentlora.com/wiki/immune-checkpoint-inhibitors/https://contentlora.com/wiki/immune-checkpoint-inhibitors/Checkpoint inhibitors such as pembrolizumab release immune brakes like PD-1 and CTLA-4. How they work, who responds, side effects and 2026 approvals.Sat, 10 Oct 2026 00:00:00 GMTWikicancer-immunotherapyhealthlife-scienceshttps://contentlora.com/wiki/in-vivo-car-t/https://contentlora.com/wiki/in-vivo-car-t/In vivo CAR-T aims to make CAR-T cells inside the body with one infusion, skipping cell manufacturing. Early 2025-2026 myeloma data, safety and limits.Sat, 10 Oct 2026 00:00:00 GMTWikicancer-immunotherapyhealthlife-scienceshttps://contentlora.com/wiki/intellia-therapeutics/https://contentlora.com/wiki/intellia-therapeutics/Intellia Therapeutics develops in vivo CRISPR therapies. Lonvo-z for hereditary angioedema is under FDA review; nex-z trials resumed after a 2025 hold.Sat, 10 Oct 2026 00:00:00 GMTWikigene-editinghealthlife-scienceshttps://contentlora.com/wiki/interventions-testing-program/https://contentlora.com/wiki/interventions-testing-program/The NIA Interventions Testing Program tests candidate anti-aging compounds in genetically diverse mice at multiple sites. Its design and key results.Sat, 10 Oct 2026 00:00:00 GMTWikilongevitylife-scienceshealthhttps://contentlora.com/wiki/intismeran-autogene/https://contentlora.com/wiki/intismeran-autogene/Intismeran autogene is Moderna and Merck's personalised mRNA cancer therapy. What it is and its 2026 phase 3 melanoma results.Sat, 10 Oct 2026 00:00:00 GMTWikivaccines-mrnahealthlife-scienceshttps://contentlora.com/wiki/lipid-nanoparticle-delivery/https://contentlora.com/wiki/lipid-nanoparticle-delivery/Lipid nanoparticles carry CRISPR and base-editor instructions into the liver. How they work in gene editing, key trials and their limits.Sat, 10 Oct 2026 00:00:00 GMTWikigene-editinglife-scienceshealthhttps://contentlora.com/wiki/loy-002/https://contentlora.com/wiki/loy-002/LOY-002 is Loyal's daily pill meant to extend senior dogs' lifespan. Its FDA status, the 1,300-dog STAY study and what remains before a decision.Sat, 10 Oct 2026 00:00:00 GMTWikilongevitylife-scienceshealthhttps://contentlora.com/wiki/moderna/https://contentlora.com/wiki/moderna/Moderna is the Cambridge, Massachusetts mRNA company behind Spikevax and the first mRNA flu vaccine. Its products, pipeline and 2026 position.Sat, 10 Oct 2026 00:00:00 GMTWikivaccines-mrnahealthlife-scienceshttps://contentlora.com/wiki/neuralink/https://contentlora.com/wiki/neuralink/Neuralink develops the N1, a wireless brain implant placed by a surgical robot. Its trials, reported results, safety record and what remains unproven.Sat, 10 Oct 2026 00:00:00 GMTWikineurotechhealthlife-scienceshttps://contentlora.com/wiki/novo-nordisk/https://contentlora.com/wiki/novo-nordisk/Novo Nordisk is the Danish maker of semaglutide (Ozempic, Wegovy, Wegovy pill). Its GLP-1 history, 2025–2026 results, pipeline and pricing pressures.Sat, 10 Oct 2026 00:00:00 GMTWikimetabolic-medicinehealthlife-scienceshttps://contentlora.com/wiki/orforglipron/https://contentlora.com/wiki/orforglipron/Orforglipron (Foundayo) is Eli Lilly's once-daily small-molecule GLP-1 pill, FDA-approved for weight management in April 2026. Trial data and pricing.Sat, 10 Oct 2026 00:00:00 GMTWikimetabolic-medicinehealthlife-scienceshttps://contentlora.com/wiki/paradromics/https://contentlora.com/wiki/paradromics/Paradromics builds Connexus, a fully implanted high-channel brain-computer interface for restoring speech. Its FDA-approved trial and first results.Sat, 10 Oct 2026 00:00:00 GMTWikineurotechhealthlife-scienceshttps://contentlora.com/wiki/partial-reprogramming/https://contentlora.com/wiki/partial-reprogramming/Partial reprogramming uses Yamanaka factors briefly to make cells act younger without erasing their identity. The evidence, risks and first human trial.Sat, 10 Oct 2026 00:00:00 GMTWikilongevitylife-scienceshealthhttps://contentlora.com/wiki/personalized-gene-editing/https://contentlora.com/wiki/personalized-gene-editing/Personalized gene editing builds an editor for one patient's mutation. The 2025 CPS1 case, how it was made and how the FDA plans to regulate it.Sat, 10 Oct 2026 00:00:00 GMTWikigene-editinghealthlife-scienceshttps://contentlora.com/wiki/personalized-neoantigen-vaccines/https://contentlora.com/wiki/personalized-neoantigen-vaccines/Individualised mRNA cancer vaccines such as intismeran autogene and autogene cevumeran: how they work, the 2026 phase 3 win and the setbacks.Sat, 10 Oct 2026 00:00:00 GMTWikicancer-immunotherapyhealthlife-scienceshttps://contentlora.com/wiki/precision-neuroscience/https://contentlora.com/wiki/precision-neuroscience/Precision Neuroscience makes Layer 7, a thin-film brain surface array with 1,024 electrodes and FDA clearance for up to 30 days of implantation.Sat, 10 Oct 2026 00:00:00 GMTWikineurotechhealthlife-scienceshttps://contentlora.com/wiki/prime-editing/https://contentlora.com/wiki/prime-editing/Prime editing is a "search-and-replace" gene-editing method. How it works, the first human data in 2025, and the road to a first filing.Sat, 10 Oct 2026 00:00:00 GMTWikigene-editinglife-scienceshealthhttps://contentlora.com/wiki/rapamycin-and-mtor/https://contentlora.com/wiki/rapamycin-and-mtor/Rapamycin blocks the mTOR growth pathway and extends lifespan in mice. The animal evidence, human trials such as PEARL, and open questions.Sat, 10 Oct 2026 00:00:00 GMTWikilongevitylife-scienceshealthhttps://contentlora.com/wiki/retatrutide/https://contentlora.com/wiki/retatrutide/Retatrutide is Eli Lilly's investigational GIP, GLP-1 and glucagon triple agonist. Phase 2 and TRIUMPH phase 3 results and its 2027 filing plan.Sat, 10 Oct 2026 00:00:00 GMTWikimetabolic-medicinehealthlife-scienceshttps://contentlora.com/wiki/self-amplifying-rna/https://contentlora.com/wiki/self-amplifying-rna/Self-amplifying RNA vaccines carry a viral copying enzyme so the RNA multiplies inside cells. How saRNA works and its first approvals.Sat, 10 Oct 2026 00:00:00 GMTWikivaccines-mrnahealthlife-scienceshttps://contentlora.com/wiki/semaglutide/https://contentlora.com/wiki/semaglutide/Semaglutide (Ozempic, Wegovy, Rybelsus, Wegovy pill) is Novo Nordisk's GLP-1 drug. Its trials, approvals, oral forms, prices and patent status in 2026.Sat, 10 Oct 2026 00:00:00 GMTWikimetabolic-medicinehealthlife-scienceshttps://contentlora.com/wiki/senolytics/https://contentlora.com/wiki/senolytics/Senolytics are drugs designed to clear senescent cells. What they are, the mouse evidence, and how human trials have fared as of 2026.Sat, 10 Oct 2026 00:00:00 GMTWikilongevitylife-scienceshealthhttps://contentlora.com/wiki/speech-neuroprostheses/https://contentlora.com/wiki/speech-neuroprostheses/Speech neuroprostheses decode attempted speech from the brain into text or a synthetic voice for people with paralysis. Key results, limits and trials.Sat, 10 Oct 2026 00:00:00 GMTWikineurotechhealthlife-scienceshttps://contentlora.com/wiki/synchron/https://contentlora.com/wiki/synchron/Synchron's Stentrode is a brain-computer interface delivered through the blood vessels, avoiding open-brain surgery. Its trials, safety data and plans.Sat, 10 Oct 2026 00:00:00 GMTWikineurotechhealthlife-scienceshttps://contentlora.com/wiki/tame-trial/https://contentlora.com/wiki/tame-trial/TAME is a proposed trial of the diabetes drug metformin designed to test whether a drug can delay aging-related diseases. Its design, history and status.Sat, 10 Oct 2026 00:00:00 GMTWikilongevitylife-scienceshealthhttps://contentlora.com/wiki/tirzepatide/https://contentlora.com/wiki/tirzepatide/Tirzepatide (Mounjaro, Zepbound) is Eli Lilly's dual GIP/GLP-1 agonist. Its trials, approvals, head-to-head data, sales and pricing as of 2026.Sat, 10 Oct 2026 00:00:00 GMTWikimetabolic-medicinehealthlife-scienceshttps://contentlora.com/wiki/tumor-infiltrating-lymphocyte-therapy/https://contentlora.com/wiki/tumor-infiltrating-lymphocyte-therapy/TIL therapy grows a patient's own tumour-derived T cells and infuses them back. The 2024 FDA approval of lifileucel, results and open questions.Sat, 10 Oct 2026 00:00:00 GMTWikicancer-immunotherapyhealthlife-scienceshttps://contentlora.com/wiki/utah-array/https://contentlora.com/wiki/utah-array/The Utah array is a grid of microelectrodes pushed into the cortex. It powered most landmark BCI studies, from cursor control in 2006 to speech in 2024.Sat, 10 Oct 2026 00:00:00 GMTWikineurotechhealthlife-scienceshttps://contentlora.com/events/cancer-immunotherapy-tracker/https://contentlora.com/events/cancer-immunotherapy-tracker/A dated, sourced timeline of cancer immunotherapy milestones from 2024 to October 2026: approvals, phase 3 readouts, safety actions and setbacks.Sat, 10 Oct 2026 00:00:00 GMTDevelopingcancer-immunotherapyhealthlife-scienceshttps://contentlora.com/events/gene-editing-tracker/https://contentlora.com/events/gene-editing-tracker/A dated, sourced timeline of gene-editing milestones: Casgevy approvals, in vivo CRISPR trials, base and prime editing, FDA actions and safety events.Sat, 10 Oct 2026 00:00:00 GMTDevelopinggene-editinghealthlife-scienceshttps://contentlora.com/events/longevity-tracker/https://contentlora.com/events/longevity-tracker/A live tracker of aging and longevity research: reprogramming trials, dog lifespan drugs, senolytic and rapamycin trials, clocks and prizes.Sat, 10 Oct 2026 00:00:00 GMTDevelopinglongevityhealthlife-scienceshttps://contentlora.com/events/metabolic-medicine-tracker/https://contentlora.com/events/metabolic-medicine-tracker/Live tracker of GLP-1 and obesity-medicine milestones: approvals, pills, triple agonists, outcome trials, Medicare coverage and pricing, 2023–2026.Sat, 10 Oct 2026 00:00:00 GMTDevelopingmetabolic-medicinehealthlife-scienceshttps://contentlora.com/events/neurotech-tracker/https://contentlora.com/events/neurotech-tracker/A dated timeline of brain-computer interface trials, approvals, speech neuroprostheses, connectome milestones and neural-data rules, 2024 to October 2026.Sat, 10 Oct 2026 00:00:00 GMTDevelopingneurotechhealthlife-scienceshttps://contentlora.com/events/vaccines-mrna-tracker/https://contentlora.com/events/vaccines-mrna-tracker/A dated, sourced timeline of mRNA vaccine, self-amplifying RNA and RNA-drug milestones and US policy changes, updated as the field moves.Sat, 10 Oct 2026 00:00:00 GMTDevelopingvaccines-mrnahealthlife-sciences