New and updated Aging and longevity biology pages on ContentLora.https://contentlora.com/enhttps://contentlora.com/wiki/altos-labs/https://contentlora.com/wiki/altos-labs/Altos Labs is a cell-rejuvenation biotech launched in 2022 with US$3 billion. Its mission, sites, leadership and where it fits in aging research.Sat, 10 Oct 2026 00:00:00 GMTWikilongevitylife-scienceshealthhttps://contentlora.com/wiki/calico-life-sciences/https://contentlora.com/wiki/calico-life-sciences/Calico is the aging research company Google announced in 2013. Its mission, AbbVie partnership, pipeline and 2026 milestones.Sat, 10 Oct 2026 00:00:00 GMTWikilongevitylife-scienceshealthhttps://contentlora.com/wiki/er-100/https://contentlora.com/wiki/er-100/ER-100 is the first partial epigenetic reprogramming therapy tested in people, in a Phase 1 trial in glaucoma and NAION. Design, early data and caveats.Sat, 10 Oct 2026 00:00:00 GMTWikilongevitylife-scienceshealthhttps://contentlora.com/wiki/interventions-testing-program/https://contentlora.com/wiki/interventions-testing-program/The NIA Interventions Testing Program tests candidate anti-aging compounds in genetically diverse mice at multiple sites. Its design and key results.Sat, 10 Oct 2026 00:00:00 GMTWikilongevitylife-scienceshealthhttps://contentlora.com/wiki/loy-002/https://contentlora.com/wiki/loy-002/LOY-002 is Loyal's daily pill meant to extend senior dogs' lifespan. Its FDA status, the 1,300-dog STAY study and what remains before a decision.Sat, 10 Oct 2026 00:00:00 GMTWikilongevitylife-scienceshealthhttps://contentlora.com/wiki/partial-reprogramming/https://contentlora.com/wiki/partial-reprogramming/Partial reprogramming uses Yamanaka factors briefly to make cells act younger without erasing their identity. The evidence, risks and first human trial.Sat, 10 Oct 2026 00:00:00 GMTWikilongevitylife-scienceshealthhttps://contentlora.com/wiki/rapamycin-and-mtor/https://contentlora.com/wiki/rapamycin-and-mtor/Rapamycin blocks the mTOR growth pathway and extends lifespan in mice. The animal evidence, human trials such as PEARL, and open questions.Sat, 10 Oct 2026 00:00:00 GMTWikilongevitylife-scienceshealthhttps://contentlora.com/wiki/senolytics/https://contentlora.com/wiki/senolytics/Senolytics are drugs designed to clear senescent cells. What they are, the mouse evidence, and how human trials have fared as of 2026.Sat, 10 Oct 2026 00:00:00 GMTWikilongevitylife-scienceshealthhttps://contentlora.com/wiki/tame-trial/https://contentlora.com/wiki/tame-trial/TAME is a proposed trial of the diabetes drug metformin designed to test whether a drug can delay aging-related diseases. Its design, history and status.Sat, 10 Oct 2026 00:00:00 GMTWikilongevitylife-scienceshealthhttps://contentlora.com/events/longevity-tracker/https://contentlora.com/events/longevity-tracker/A live tracker of aging and longevity research: reprogramming trials, dog lifespan drugs, senolytic and rapamycin trials, clocks and prizes.Sat, 10 Oct 2026 00:00:00 GMTDevelopinglongevityhealthlife-scienceshttps://contentlora.com/analysis/aging-as-a-disease-debate/https://contentlora.com/analysis/aging-as-a-disease-debate/Is aging a treatable condition, and is the evidence strong enough? The debate over animal data, weak human trials, unvalidated clocks and FDA rules.Sat, 10 Oct 2026 00:00:00 GMTAnalysislongevityhealthlife-scienceshttps://contentlora.com/explain/hallmarks-of-aging/https://contentlora.com/explain/hallmarks-of-aging/What the twelve hallmarks of aging are, how scientists decide what counts as one, and why the framework is useful but contested.Sat, 10 Oct 2026 00:00:00 GMTExplainerlongevitylife-scienceshealthhttps://contentlora.com/explain/how-aging-interventions-are-tested/https://contentlora.com/explain/how-aging-interventions-are-tested/Why testing drugs against aging is hard: mouse lifespan studies, dog trials, human trial designs like TAME, and the lack of a regulatory route for aging drugs.Sat, 10 Oct 2026 00:00:00 GMTExplainerlongevitylife-scienceshealthhttps://contentlora.com/explain/how-epigenetic-clocks-work/https://contentlora.com/explain/how-epigenetic-clocks-work/How DNA methylation clocks such as Horvath, GrimAge and DunedinPACE estimate biological age, how reliable they are, and why validation matters.Sat, 10 Oct 2026 00:00:00 GMTExplainerlongevitylife-scienceshealthhttps://contentlora.com/explain/longevity/https://contentlora.com/explain/longevity/A sourced crash course on aging biology: hallmarks, epigenetic clocks, senolytics, reprogramming, rapamycin and who leads, as of October 2026.Sat, 10 Oct 2026 00:00:00 GMTExplainerlongevitylife-scienceshealth