mRNA and next-gen vaccines
mRNA platforms, new vaccine technologies and RNA-based therapeutics.
- WikiAlnylam PharmaceuticalsAlnylam developed the first approved RNAi drug and is a major siRNA drugmaker. Its medicines, the Amvuttra heart approval and its 2026 pipeline.Updated
- WikiBioNTechBioNTech is the Mainz-based company that co-developed the Pfizer-BioNTech COVID-19 vaccine and is now focused on mRNA cancer immunotherapy.Updated
- WikiCEPI (Coalition for Epidemic Preparedness Innovations)CEPI funds vaccines against epidemic threats and leads the 100 Days Mission. Its role in mRNA and pandemic preparedness, and its 2027-2031 plan.Updated
- WikiIntismeran autogene (mRNA-4157/V940)Intismeran autogene is Moderna and Merck's personalised mRNA cancer therapy. What it is and its 2026 phase 3 melanoma results.Updated
- WikiModernaModerna is the Cambridge, Massachusetts mRNA company behind Spikevax and the first mRNA flu vaccine. Its products, pipeline and 2026 position.Updated
- WikiSelf-amplifying RNA (saRNA)Self-amplifying RNA vaccines carry a viral copying enzyme so the RNA multiplies inside cells. How saRNA works and its first approvals.Updated
- AnalysisThe US mRNA vaccine policy debate, 2025-2026How US mRNA vaccine policy changed in 2025-2026: FDA label limits, BARDA cuts, ACIP reconstitution and the court case, with each side's arguments.Updated
- ExplainerHow lipid nanoparticles deliver RNALipid nanoparticles carry mRNA and siRNA into cells. Their four ingredients, how they escape the endosome, and why most end up in the liver.Updated
- ExplainerHow mRNA vaccines workHow an mRNA vaccine turns a genetic message into an immune response, why modified nucleosides mattered, and what the platform can and cannot do.Updated
- ExplainerHow RNA silencing drugs work (siRNA and antisense)How siRNA and antisense oligonucleotide drugs switch off disease-causing genes at the RNA level, and where the field stands in 2026.Updated