Aging and longevity biology
The biology of aging and research on interventions that may extend healthy lifespan.
- WikiAltos LabsAltos Labs is a cell-rejuvenation biotech launched in 2022 with US$3 billion. Its mission, sites, leadership and where it fits in aging research.Updated
- WikiCalico Life SciencesCalico is the aging research company Google announced in 2013. Its mission, AbbVie partnership, pipeline and 2026 milestones.Updated
- WikiER-100 (Life Biosciences' reprogramming therapy)ER-100 is the first partial epigenetic reprogramming therapy tested in people, in a Phase 1 trial in glaucoma and NAION. Design, early data and caveats.Updated
- WikiNIA Interventions Testing Program (ITP)The NIA Interventions Testing Program tests candidate anti-aging compounds in genetically diverse mice at multiple sites. Its design and key results.Updated
- WikiLOY-002 (Loyal's senior dog lifespan drug)LOY-002 is Loyal's daily pill meant to extend senior dogs' lifespan. Its FDA status, the 1,300-dog STAY study and what remains before a decision.Updated
- WikiPartial reprogrammingPartial reprogramming uses Yamanaka factors briefly to make cells act younger without erasing their identity. The evidence, risks and first human trial.Updated
- WikiRapamycin and mTOR inhibitionRapamycin blocks the mTOR growth pathway and extends lifespan in mice. The animal evidence, human trials such as PEARL, and open questions.Updated
- WikiSenolyticsSenolytics are drugs designed to clear senescent cells. What they are, the mouse evidence, and how human trials have fared as of 2026.Updated
- WikiTAME trial (Targeting Aging with Metformin)TAME is a proposed trial of the diabetes drug metformin designed to test whether a drug can delay aging-related diseases. Its design, history and status.Updated
- AnalysisCan aging be treated? Evidence, hype and the regulatory gapIs aging a treatable condition, and is the evidence strong enough? The debate over animal data, weak human trials, unvalidated clocks and FDA rules.Updated
- ExplainerThe hallmarks of aging, explainedWhat the twelve hallmarks of aging are, how scientists decide what counts as one, and why the framework is useful but contested.Updated
- ExplainerHow anti-aging interventions are tested, from mice to peopleWhy testing drugs against aging is hard: mouse lifespan studies, dog trials, human trial designs like TAME, and the lack of a regulatory route for aging drugs.Updated
- ExplainerHow epigenetic clocks and aging biomarkers workHow DNA methylation clocks such as Horvath, GrimAge and DunedinPACE estimate biological age, how reliable they are, and why validation matters.Updated